GLP-1 & incretin medicines

Soliqua 100/33

insulin glargine + lixisenatide · Basal insulin + GLP-1 receptor agonist combination · Sanofi

✓Last reviewed · Written by Dr. George Grunberger · Medical review: pending — clinician review in progress · How we review

In short

Soliqua (insulin glargine + lixisenatide) is a basal insulin + GLP-1 receptor agonist combination made by Sanofi, used for blood sugar control in adults with type 2 diabetes. Schedule: once daily. It is prescription-only in the US and Canada.

FormPrefilled pen
How oftenOnce daily
United StatesFDA-approved. Standalone lixisenatide (Adlyxin) has been discontinued; lixisenatide remains available inside Soliqua.
CanadaCheck the Drug Product Database.
PrescriptionRequired

What it is used for

  • Blood sugar control in adults with type 2 diabetes

Soliqua dosage

Per the official label. Your prescriber sets your dose — never change it on your own.

Soliqua label dosing schedule
1DoseSet in units by your prescriber based on prior therapy and blood sugar; injected within the hour before the first meal of the day

How to take it

Once daily within 1 hour before the first meal.

Storage

Refrigerate before use; after first use, room temperature up to 28 days.

How it works

How GLP-1 medicines workGLP-1 medicines raise insulin after meals, lower glucagon, slow stomach emptying and reduce appetite.1More insulinreleased after meals,only when sugar is high2Less glucagonso the liver makesless sugar3Slower stomachfood leaves the stomachmore slowly4Less appetitethe brain signalsfullness sooner
The four main actions of GLP-1 receptor agonists, as described on their labels.

Side effects

Common

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Abdominal pain
  • Indigestion / heartburn
  • Fatigue
  • Decreased appetite

Serious — get medical help

  • Pancreatitis (severe stomach pain that may spread to the back)
  • Gallbladder problems, including gallstones
  • Low blood sugar when combined with insulin or a sulfonylurea
  • Kidney problems, often from dehydration after vomiting or diarrhea
  • Serious allergic reactions
  • Diabetic retinopathy complications (people with type 2 diabetes)
  • Pulmonary aspiration during anesthesia or deep sedation — tell your surgical team you take it

Who should not use it

  • Personal or family history of medullary thyroid carcinoma, or MEN 2
  • Prior serious allergic reaction to the drug or its ingredients
  • Pregnancy (stop before a planned pregnancy as advised by your prescriber)
  • Use together with another GLP-1 receptor agonist

Cost

Brand-only; check manufacturer savings programs.

GLP-1 cost without insurance →

How to buy Soliqua legally

  1. Get a prescription from your doctor or a licensed telehealth provider.
  2. Fill it at a licensed pharmacy.
  3. Verify any online pharmacy first (US: safe.pharmacy; Canada: your provincial pharmacy college register).

Buying legally in the USA → Buying legally in Canada →

Frequently asked questions

Does Soliqua have the thyroid boxed warning?

No. Lixisenatide-containing products do not carry that boxed warning, though general GLP-1 precautions still apply.

Also searched as: lixisenatide, Adlyxin, insulin glargine and lixisenatide, Soliqua pen

Sources

Checked against these primary sources on .

GLP-1 & incretin medicinesXultophy 100/3.6insulin degludec + liraglutide · Once dailyInsulinsInsulin glargine: Lantus, Basaglar, Semglee, Rezvoglar, Toujeoinsulin glargine · Once daily
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