Tresiba (Degludec): Why Flexible Timing Matters
Tresiba (insulin degludec) is an ultra-long basal insulin with flexible dose timing. How the 8-hour rule works, U-100 vs U-200 pens, storage and cost.
3 min read
Key takeaways
Tresiba is an ultra-long-acting basal insulin taken once a day. Its long action allows flexible timing — the label only requires at least 8 hours between doses. It comes in U-100 and U-200 pens, and unbranded insulin degludec is available in the US.
Tresiba at a glance
| Generic name | insulin degludec |
|---|---|
| Made by | Novo Nordisk |
| Type | Ultra-long-acting (basal) insulin |
| Form | Pens (U-100, U-200), vials |
| How often | Once daily |
| United States | FDA-approved; unbranded insulin degludec is available. |
| Canada | Available in Canada. |
The flexibility, in practice
If you normally inject at 8 a.m. but forget until lunchtime, you can still take that day's dose, as long as at least 8 hours separate it from the next one. That makes degludec useful for shift workers and travelers.
U-100 or U-200
U-200 pens hold twice the insulin per mL, so they suit people who need larger doses. The pen counter shows the units you get, so you do not need to convert — but never draw U-200 out of a pen with a syringe.
Who can use it
Tresiba is approved for basal control in diabetes in adults and children aged 1 and older.
Low blood sugar
Know your low-sugar plan. Signs include shaking, sweating, a fast heartbeat, hunger, confusion and irritability. A common approach is the rule of 15: take 15 g of fast-acting carbohydrate (glucose tablets, juice or regular soda), recheck after 15 minutes, and repeat if still low. Make sure someone close to you knows how to use rescue glucagon.
Storage
Unopened: refrigerate. In use: up to 56 days at room temperature or in the fridge.
In the US, Medicare caps insulin out-of-pocket costs at $35 a month, and manufacturers run $35 programs for many people with commercial insurance or none. Check eligibility before paying list price.
Frequently asked questions
Can I take Tresiba at a different time every day?
Yes, within the label's rule of at least 8 hours between doses. A regular time still helps you remember.
Tresiba or glargine?
Both are basal insulins; degludec lasts longer and allows more flexible timing. Coverage often decides.
Why does it take days for dose changes to show?
Because it is so long-acting, it takes a few days to reach a steady level after each change.
Keep reading
Sources
Checked against these primary sources on .
General information based on the official label. It does not replace advice from your prescriber or pharmacist.