Wegovy pill vs Foundayo: the two weight-loss pills compared
Quick answer
The Wegovy pill (oral semaglutide) and Foundayo (orforglipron) compared: how to take them, results, doses and cost. The Wegovy pill showed larger average weight loss in trials; Foundayo is easier to take because it has no fasting rule. Both carry the thyroid C-cell boxed warning.
Side by side
| Feature | Wegovy pill | Foundayo |
|---|---|---|
| Molecule | Semaglutide (peptide) | Orforglipron (small molecule) |
| FDA approval | December 22, 2025 | April 1, 2026 |
| How to take | Fasting, ≤4 oz water, wait 30 min | Any time, with or without food |
| Maintenance dose | 25 mg daily | 5.5 to 17.2 mg daily |
| Avg. weight loss in trials | Comparable to Wegovy 2.4 mg injection | About 12% at highest dose (72 weeks) |
Which one is right for you?
The Wegovy pill showed larger average weight loss in trials; Foundayo is easier to take because it has no fasting rule. Both carry the thyroid C-cell boxed warning.
Both are prescription medicines. Which one fits depends on your diagnosis, history and coverage — decide with your prescriber.
Sources
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