Foundayo
orforglipron · Small-molecule (non-peptide) oral GLP-1 receptor agonist · Eli Lilly
In short
Foundayo (orforglipron) is a small-molecule (non-peptide) oral GLP-1 receptor agonist made by Eli Lilly, used for weight reduction and long-term maintenance in adults with obesity, or overweight with at least one weight-related condition. Schedule: once daily. It is prescription-only in the US and Canada.
What it is used for
- Weight reduction and long-term maintenance in adults with obesity, or overweight with at least one weight-related condition
Foundayo dosage
Per the official label. Your prescriber sets your dose — never change it on your own.
| 1Days 1–30 | 0.8 mg daily |
|---|---|
| 2Days 31–60 | 2.5 mg daily |
| 3Days 61–90 | 5.5 mg daily (lowest maintenance dose) |
| 4If needed | 9 mg, 14.5 mg or 17.2 mg daily, each step after at least 30 days |
| 5Maximum | 17.2 mg daily (9 mg with strong CYP3A4 inhibitors) |
How to take it
Take once daily at any time, with or without food or water — no fasting rule.
Storage
Room temperature in the original container.
Side effects
Common
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Abdominal pain
- Indigestion / heartburn
- Fatigue
- Decreased appetite
Serious — get medical help
- Pancreatitis (severe stomach pain that may spread to the back)
- Gallbladder problems, including gallstones
- Low blood sugar when combined with insulin or a sulfonylurea
- Kidney problems, often from dehydration after vomiting or diarrhea
- Serious allergic reactions
- Diabetic retinopathy complications (people with type 2 diabetes)
- Pulmonary aspiration during anesthesia or deep sedation — tell your surgical team you take it
Who should not use it
- Personal or family history of medullary thyroid carcinoma, or MEN 2
- Prior serious allergic reaction to the drug or its ingredients
- Pregnancy (stop before a planned pregnancy as advised by your prescriber)
- Use together with another GLP-1 receptor agonist
Cost
LillyDirect self-pay launched at $149/month (0.8 mg), $199 (2.5 mg) and $299 (higher doses). With commercial coverage, a savings card may bring it to $25/month. Verify before filling.
How to buy Foundayo legally
- Get a prescription from your doctor or a licensed telehealth provider.
- Fill it at a licensed pharmacy, or through the manufacturer's self-pay pharmacy.
- Verify any online pharmacy first (US: safe.pharmacy; Canada: your provincial pharmacy college register).
Common questions
Frequently asked questions
How is Foundayo different from the Wegovy pill?
Foundayo is a small molecule with no food or water restrictions. The Wegovy pill is semaglutide and must be taken fasting.
How much weight do people lose on Foundayo?
In the 72-week ATTAIN-1 trial, the highest dose averaged about 12% body-weight loss versus about 1% on placebo.
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Sources
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