GLP-1 & incretin medicines

Wegovy pill

oral semaglutide 25 mg · GLP-1 receptor agonist (oral) · Novo Nordisk

✓Last reviewed · Written by Dr. George Grunberger · Medical review: pending — clinician review in progress · How we review

In short

Wegovy pill (oral semaglutide 25 mg) is a GLP-1 receptor agonist (oral) made by Novo Nordisk, used for weight reduction and long-term maintenance in adults with obesity, or overweight with a weight-related condition (see the label for any additional indications). Schedule: once daily. It is prescription-only in the US and Canada.

FormTablet
How oftenOnce daily
United StatesFDA-approved December 22, 2025 — the first oral GLP-1 for weight loss. US launch January 2026.
CanadaCheck the Health Canada Drug Product Database for current status. The European Commission approved it EU-wide in July 2026.
PrescriptionRequired
⚠ Boxed warning: risk of thyroid C-cell tumors. Do not use if you or a family member has had medullary thyroid carcinoma (MTC) or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

What it is used for

  • Weight reduction and long-term maintenance in adults with obesity, or overweight with a weight-related condition (see the label for any additional indications)

Wegovy pill dosage

Per the official label. Your prescriber sets your dose — never change it on your own.

Wegovy pill label dosing schedule
1Days 1–301.5 mg daily
2Days 31–604 mg daily
3Days 61–909 mg daily
4Day 91 on25 mg daily (maintenance)
Wegovy pill dose stepsDays 1–30: 1.5 mg; Days 31–60: 4 mg; Days 61–90: 9 mg; Day 91 on: 25 mg1.5 mgDays 1–304 mgDays 31–609 mgDays 61–9025 mgDay 91 on
Wegovy pill label titration, step by step. Doses go up only as tolerated and as your prescriber decides.

How to take it

Take on an empty stomach with up to 4 oz of water. Wait at least 30 minutes before food, drink or other oral medicines. Swallow whole.

Storage

Keep in the original container, protected from moisture.

Side effects

Common

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Abdominal pain
  • Indigestion / heartburn
  • Fatigue
  • Decreased appetite

Serious — get medical help

  • Pancreatitis (severe stomach pain that may spread to the back)
  • Gallbladder problems, including gallstones
  • Low blood sugar when combined with insulin or a sulfonylurea
  • Kidney problems, often from dehydration after vomiting or diarrhea
  • Serious allergic reactions
  • Diabetic retinopathy complications (people with type 2 diabetes)
  • Pulmonary aspiration during anesthesia or deep sedation — tell your surgical team you take it

Who should not use it

  • Personal or family history of medullary thyroid carcinoma, or MEN 2
  • Prior serious allergic reaction to the drug or its ingredients
  • Pregnancy (stop before a planned pregnancy as advised by your prescriber)
  • Use together with another GLP-1 receptor agonist

Cost

US self-pay through NovoCare started at $149/month for starter doses; higher doses about $299/month. Promotional prices change — verify before filling.

GLP-1 cost without insurance →

How to buy Wegovy pill legally

  1. Get a prescription from your doctor or a licensed telehealth provider.
  2. Fill it at a licensed pharmacy, or through the manufacturer's self-pay pharmacy.
  3. Verify any online pharmacy first (US: safe.pharmacy; Canada: your provincial pharmacy college register).

Buying legally in the USA → Buying legally in Canada →

Frequently asked questions

Is the Wegovy pill as effective as the injection?

In trials, 25 mg daily produced weight loss comparable to the 2.4 mg weekly injection. Individual results vary.

Why does the pill need an empty stomach?

Food and other drinks sharply reduce semaglutide absorption from the tablet.

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Sources

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