Soliqua 100/33: How the Insulin–GLP-1 Combo Works
Soliqua combines insulin glargine and lixisenatide in one daily pen. Who it suits, how dosing in units works, timing before breakfast, and low-sugar safety.
3 min read
Key takeaways
Soliqua 100/33 puts long-acting insulin glargine and the GLP-1 lixisenatide in one pen. You inject it once a day within the hour before your first meal. The dose is set in units by your prescriber — each unit gives both medicines.
Soliqua at a glance
| Generic name | insulin glargine + lixisenatide |
|---|---|
| Made by | Sanofi |
| Type | Basal insulin + GLP-1 receptor agonist combination |
| Form | Prefilled pen |
| How often | Once daily |
| United States | FDA-approved. Standalone lixisenatide (Adlyxin) has been discontinued; lixisenatide remains available inside Soliqua. |
| Canada | Check the Drug Product Database. |
Why combine them
Basal insulin controls fasting sugar; lixisenatide mainly blunts the rise after meals. Combining them can mean one injection instead of two and sometimes a lower insulin dose than insulin alone.
How dosing works
Your prescriber chooses a starting dose in units based on your previous treatment and adjusts it from your fasting glucose. Because the ratio is fixed, you cannot change one ingredient without the other — that is why only your care team should change the dose.
Daily routine
- Inject within 1 hour before the first meal of the day.
- Attach a new needle and prime the pen as the leaflet shows.
- Rotate injection sites to prevent skin lumps.
Low blood sugar
Soliqua contains insulin, so hypoglycemia is possible. Know the signs — shaking, sweating, confusion — and carry fast sugar. A common rule is 15 g of fast-acting carbohydrate, then recheck in 15 minutes.
Storage and supply
Refrigerate unused pens; once in use, keep at room temperature for up to 28 days. Standalone lixisenatide (Adlyxin) is discontinued, but it remains available inside Soliqua.
Frequently asked questions
Can I take Soliqua with another GLP-1?
No. It already contains a GLP-1 receptor agonist; it should not be combined with another.
What if I miss the pre-breakfast dose?
Follow your prescriber's instructions; the label advises taking the next dose at the usual time rather than doubling.
Is Soliqua for type 1 diabetes?
No. It is approved for adults with type 2 diabetes.
Keep reading
Sources
Checked against these primary sources on .
General information based on the official label. It does not replace advice from your prescriber or pharmacist.