Wegovy vs Zepbound: semaglutide vs tirzepatide for weight loss
Quick answer
Wegovy (semaglutide) vs Zepbound (tirzepatide): weight-loss results, dosing, side effects and self-pay costs compared. In head-to-head research tirzepatide produced greater average weight loss than semaglutide 2.4 mg. Wegovy HD narrows that gap. Side effects are similar and mostly gastrointestinal.
Side by side
| Feature | Wegovy | Zepbound |
|---|---|---|
| Molecule | Semaglutide (GLP-1) | Tirzepatide (GIP + GLP-1) |
| Dosing | Weekly; up to 2.4 mg or 7.2 mg (HD) | Weekly; up to 15 mg |
| Extra approvals | Heart risk reduction, MASH | Obstructive sleep apnea |
| Oral option | Wegovy pill | None (Lilly's oral is Foundayo, a different drug) |
| Self-pay channel | NovoCare & partner pharmacies | LillyDirect (vials and pens) |
Which one is right for you?
In head-to-head research tirzepatide produced greater average weight loss than semaglutide 2.4 mg. Wegovy HD narrows that gap. Side effects are similar and mostly gastrointestinal.
Both are prescription medicines. Which one fits depends on your diagnosis, history and coverage — decide with your prescriber.
Sources
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