Ozempic tablets (formerly Rybelsus)
oral semaglutide · GLP-1 receptor agonist (oral) · Novo Nordisk
In short
Ozempic tablets (oral semaglutide) is a GLP-1 receptor agonist (oral) made by Novo Nordisk, used for blood sugar control in adults with type 2 diabetes and lower risk of major cardiovascular events in adults with type 2 diabetes at high risk. Schedule: once daily. It is prescription-only in the US and Canada.
What it is used for
- Blood sugar control in adults with type 2 diabetes
- Lower risk of major cardiovascular events in adults with type 2 diabetes at high risk
Ozempic tablets dosage
Per the official label. Your prescriber sets your dose — never change it on your own.
| 1Days 1–30 | 1.5 mg once daily (Rybelsus: 3 mg) |
|---|---|
| 2Day 31 on | 4 mg once daily (Rybelsus: 7 mg) |
| 3If more control is needed | 9 mg once daily after at least 30 days (Rybelsus: 14 mg) |
How to take it
Take first thing in the morning on an empty stomach with no more than 4 oz (120 mL) of plain water. Wait at least 30 minutes before eating, drinking or taking other oral medicines. Swallow whole.
Storage
Keep in the original bottle, away from light and moisture.
Side effects
Common
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Abdominal pain
- Indigestion / heartburn
- Fatigue
- Decreased appetite
Serious — get medical help
- Pancreatitis (severe stomach pain that may spread to the back)
- Gallbladder problems, including gallstones
- Low blood sugar when combined with insulin or a sulfonylurea
- Kidney problems, often from dehydration after vomiting or diarrhea
- Serious allergic reactions
- Diabetic retinopathy complications (people with type 2 diabetes)
- Pulmonary aspiration during anesthesia or deep sedation — tell your surgical team you take it
Who should not use it
- Personal or family history of medullary thyroid carcinoma, or MEN 2
- Prior serious allergic reaction to the drug or its ingredients
- Pregnancy (stop before a planned pregnancy as advised by your prescriber)
- Use together with another GLP-1 receptor agonist
Cost
Brand-only in the US. Check NovoCare and manufacturer savings programs.
How to buy Ozempic tablets legally
- Get a prescription from your doctor or a licensed telehealth provider.
- Fill it at a licensed pharmacy, or through the manufacturer's self-pay pharmacy.
- Verify any online pharmacy first (US: safe.pharmacy; Canada: your provincial pharmacy college register).
Frequently asked questions
Can I swap Rybelsus and Ozempic tablets mg for mg?
No. The new tablets absorb better, so doses differ: Rybelsus 7 mg corresponds to Ozempic 4 mg, and 14 mg to 9 mg. Your prescriber handles the switch.
Why the name change?
Novo Nordisk moved oral semaglutide for diabetes under the better-known Ozempic name in 2026.
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Sources
Checked against these primary sources on .